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Yildirim Cinar, A great. Mete Senyol, Kamber Duman, Bloodstream viscosity and you may hypertension: role away from temperatures and you will hyperglycemia, American Record out of Blood pressure levels, Volume step step step 14, Matter 5, , Pages 433–438,

Conceptual

We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.

The goal of our data will be to research the relationship certainly heat, glucose concentration, and you can viscosity off blood and you may plasma, and estimate the consequences for the blood pressure level (BP) according to Hagen-Poiseuille’s hydrodynamics equation.

If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F₁ ? F₂) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F₁ ? F₂), where ? is the viscosity of the fluid, F₁ and F₂ are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.

Bloodstream viscosity and you can blood pressure level: character of heat and you may hyperglycemia

It has been revealed you to definitely between % and % thinking out-of hematocrit, the 11% escalation in hematocrit develops blood viscosity because of the 20%. Inside condition, based on Poiseuille’s equation, blood circulation rates minimizes by %, which could produce tissues ischemia. To store the fresh new circulatory program inside balance (that’s, staying the circulate rate enough and you may stopping cells ischemia), good 20% rise in BP otherwise 4.66% vasodilation is required. step three not, the human circulatory experience maybe not an exact finalized program, as the blood viscosity will likely be altered to your intake of dining or medicines. 4–8 In addition, the results of fat and of certain drugs to your bloodstream viscosity and you can hemodynamics eg BP was in fact reported. Given that atherosclerotic vessels cannot dilate good enough just like the a response to vasodilator medicines, it’s been advised that increased blood viscosity can simply feel paid having a beneficial BP boost in such as items. 9–several In addition http://www.datingranking.net/married-hookup-apps to, the fresh relationships one of BP, headache, coagulation, circulation velocity, and you will bloodstream viscosity was in fact revealed via the beliefs away from hemodynamics. 13, 14