Кулинарный портал

As more was discovered towards molecular and you can mobile biology off Age. histolytica, you will find higher possibility subsequent comprehension of the newest pathogenesis off amebiasis.

Lifestyle Cycle And BIOLOGY

Individuals would be the top understood tank getting E. histolytica (105). An element of the source of transmission is the chronically contaminated person. Feces contaminated toward tumor sorts of the fresh parasite inate new dining or liquid. As well, there was a recommendation from zoonotic sign, however, this is not clear (21, twenty two, 113). Experimental infection having Age. histolytica was built in certain pets such as for example animals, kittens, mice, monkeys, or other laboratory pets. Such dogs may to get people challenges as a result of personal experience of human beings. Natural E. histolytica bacterial infections with strains morphologically like Age. histolytica have been discovered in monkeys (21, 22). In one single analysis, E. histolytica was receive microscopically inside the tarnished fecal smears away from half a dozen kinds off locally available Kenyan nonhuman primates (137). There might be some creature reservoirs out of Elizabeth. histolytica (pet, monkeys, and most likely pigs), even so they represent an incredibly short source of human issues compared which have individuals themselves (60). The necessity of wildlife (primates) during the zoonotic infection are learnt because of the Jackson mais aussi al., exactly who used zymodeme research to research if or not Age. histolytica takes place because the a genuine zoonosis (96). Yet not, there aren’t any profile regarding sporadic zoonotic alert from circumstances anywhere between contaminated pet and you may people, even in the event E. histolytica was most commonly of pet (kitties, pet, nonhuman primates, etcetera.).

Infective cysts may be bequeath by arthropods eg cockroaches and flies, indicating why these insects are able to play a rare but important role in the signal (93, 230).

The life span years out of Elizabeth. histolytica is easy. It include an infective tumor phase and a great multiplying trophozoite phase. Human beings was contaminated because of the consuming such infective cysts, and that travel from gut lumen towards short bowels (critical ileum), in which for each and every excysts to create eight child trophozoites. The trophozoites is actually motile models, and that follow and you can inhabit intestinal epithelial cells hence range the latest gastrointestinal tract. Trophozoites disperse from the stretching coming forecasts off cytoplasm, called pseudopodia, and that navigoi tГ¤lle sivustolle remove them along. They also make use of these projections so you’re able to encompass and you will engulf dinner particles. This new cytoplasm seem to contains of many purple bloodstream muscle (RBCs) which have been consumed. The trophozoites off Elizabeth. histolytica always have one nucleus. Trophozoites can be destroyed about external ecosystem, degenerating within seconds.

The trophozoite from Elizabeth. histolytica can convert to a good precyst function having good nucleus (E. coli precysts keeps several nuclei), and this mode develops with the a great tetranucleated tumor because migrates down-and-out of your anus. The fresh precyst contains aggregates away from ribosomes, called chromatoid bodies, along with food vacuoles that will be extruded once the telephone shrinks to become a mature cyst. Simple fact is that adult tumefaction one, whenever used contaminated dinner otherwise water, are infectious. In the process of are tetranucleated, the brand new nucleus of the tumefaction divides double. Chromatoid regulators and you will glycogen vacuoles cannot be viewed at this time (46, 64, 105).

To the application of plenty of the new unit biology-dependent procedure, astounding advances have been made within our knowledge of the latest prognosis, pure history, and you will epidemiology out-of amebiasis

Cysts can also be are still alive beyond your machine to own months or months, especially below moist standards (129), but they are quickly forgotten at temperature below ?5°C as well as forty°C (93). Cysts aren’t invasive, but trophozoites normally penetrate the newest gastrointestinal mucosa (46). From that point, the new trophozoites are able to move with other areas, causing extraintestinal bacterial infections.

Like other protozoa, Elizabeth. histolytica appears not able to de- novo purine synthesis. Biochemical study has actually indicated that glutathione isn’t introduce. Thus, Age. histolytica differs from higher eukaryotes. it uses pyrophosphate unlike ATP (133). The cytoplasm of one’s cyst try vacuolated with several glycogen deposits, obvious because of the long lasting spots instance metal-hematoxylin, one to reduce in size and you can amount since tumor develops. And visible is actually crystalline arrays regarding aggregated ribosomes in the cytoplasm of your own trophozoite (89, 183).